Journal Reviews

Akimba mice, a model of human diabetic retinopathy

1 October 2014 | | Retina / Uvea / Vitreous | Akimba, BRB, PLVAP, blood-retinal barrier, diabetic macular edema, diabetic retinopathy, mouse models, retina

Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...

New mouse model of diabetes mellitus

1 April 2014 | | Retina / Uvea / Vitreous | aldose reductase, cell signaling P-ERK1/2, P-SAPK/JNK, P-Akt, diabetic rats, diabetic retinopathy, green fluorescent proteins, growth factors VEGF, bFGF, TGF-β, retinal vascular changes, transgenic diabetic mouse models

Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...